Early-onset androgenetic alopecia and endocrine disruptors

Androgenetic Alopecia

Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

Androgenetic alopecia (AGA) is a highly heritable condition and the most common form of hair loss in humans. Susceptibility loci have been described on the X chromosome and chromosome 20, but these loci explain a minority of its heritable variance. We conducted a large-scale meta-analysis of seven genome-wide association studies for early-onset AGA in 12,806 individuals of European ancestry. Wh...

Dyslipidemia in patients with early onset androgenetic alopecia and risk of coronary artery disease

The Gulf Journal of Dermatology and Venereology INTRODUCTION Androgenetic alopecia (AGA) is a hereditary and androgen-dependent progressive thinning of the scalp hair in a defined pattern. It is a common dermatological disorder affecting more men and occasionally women, with significant negative impact on their social and psychological well being. AGA commonly begins by 20 years of age and affe...

Inflammation in androgenetic alopecia

Years of research have led to the conclusion that androgenetic alopecia may be a result of an alteration in the hair growth cycle and/or a premature aging of the pilosebaceous unit. The etiology of androgenetic alopecia has been defined as multifactorial or even polygenic in nature. The fact that the success rate of treatment with either antihypertensive agents or modulators of androgen metabol...

Male androgenetic alopecia.

IMPORTANCE OF THE FIELD Androgenetic alopecia affects up to 80% of males by the age of 80. The synonym 'male-pattern hair loss' highlights the fact that hair loss occurs in a defined and reproducible pattern. Hair loss results in reduced self esteem, loss of confidence and anxiety in affected men. An effective treatment for hair baldness would be desirable. AREAS COVERED IN THIS REVIEW In and...